2. Apoptosis
  3. Apoptosis
  4. PP-60

PP-60 is an apoptosis inducer. PP-60 inhibits the proliferation of cancer cells and induces cancer cell apoptosis. PP-60 exerts anti-tumor effects in nude mouse liver tumor models. PP-60 is applicable to research related to cancers such as liver cancer, lung cancer, and prostate cancer.

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PP-60

PP-60 Chemical Structure

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PP-60 Related Antibodies

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Description

PP-60 is an apoptosis inducer. PP-60 inhibits the proliferation of cancer cells and induces cancer cell apoptosis. PP-60 exerts anti-tumor effects in nude mouse liver tumor models. PP-60 is applicable to research related to cancers such as liver cancer, lung cancer, and prostate cancer[1].

In Vitro

PP-60 (24 h) exhibits potent antiproliferative activity against HepG2, A549 and PC-3 cells, with IC50 values of 1.73, 2.15 and 2.69 μM[1].
PP-60 (2 μM; 2-4 h) exhibits excellent cellular uptake capacity[1].
PP-60 (0-5 μM) inhibits G2 phase cell cycle progression in HepG2 cells in a dose-dependent manner, and the percentage of cells in the G2 phase reaches approximately 35% at a concentration of 5 μM[1].
PP-60 (0-5 μM, 6 h) induces apoptosis in HepG2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PP-60 Related Antibodies

Immunofluorescence[1]

Cell Line: HepG2 cells
Concentration: 2 μM
Incubation Time: 2, 4 h
Result: Increased FITC fluorescence signal intensity indicates a stronger cellular uptake capacity.

Apoptosis Analysis[1]

Cell Line: HepG2 cells
Concentration: 0, 1, 2, 5 μM
Incubation Time: 6 h
Result: Induced apoptosis, at a concentration of 5 μM, the apoptosis rate is approximately 80%.
In Vivo

PP-60 (0.5 mg per mouse; intratumoral injection; administered on days 1, 6, and 15) exhibits potent antitumor activity in the HepG2 xenograft nude mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice (female; HepG2 (2 × 106 cells/mouse) xenograft model)[1]
Dosage: 0.5 mg per mouse
Administration: intratumoral injection; on day 1, 6, and 15
Result: Exhibited potent antitumor activity.
Reduced tumor volume; decreased tumor weight; showed the highest caspase 3 positive staining; reduced Ki67 positive cells to the lowest level; induced significant tumor cell apoptosis.
Molecular Weight

3103.74

Formula

C142H252N36O40
Sequence

Ac-{Arg(β-Glu(1→4)-α-Glu)}-Leu-{(S)-2-(4-pentenyl)alanine}-Lys-Asp-Lys-{(S)-2-(4-pentenyl)alanine}-Lys-Gly-Ile-Gly-Lys-Leu-Ala-Gly-Lys-Ala-Ala-Leu-Gly-Ala-{(S)-2-(4-pentenyl)alanine}--Lys-Thr-Leu-{(S)-2-(4-pentenyl)alanine}-NH2 (RCM bridge: {S5}3-{S5}7, {S5}22-{S5}26)
Sequence Shortening

Ac-{Arg(β-Glu(1→4)-α-Glu)}-L-{S5}-KDK-{S5}-KGIGKLAGKAALGA-{S5}-KTL-{S5}-NH2 (RCM bridge: {S5}3-{S5}7, {S5}22-{S5}26)
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PP-60 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PP-60PP60PP 60ApoptosisapoptosisHepG2 xenograft nude miceHepG2 cellsA549 cellsPC-3 cellsliver cancerlung cancerprostate cancerInhibitorinhibitorinhibit

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