1. PROTAC
    Apoptosis
  2. Ligands for Target Protein for PROTAC
    Bcl-2 Family
  3. PROTAC Bcl-xL ligand-1

PROTAC Bcl-xL ligand-1 

Cat. No.: HY-139304
Handling Instructions

PROTAC Bcl-xL ligand-1 is a ligand for Bcl-xL that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

PROTAC Bcl-xL ligand-1 Chemical Structure

PROTAC Bcl-xL ligand-1 Chemical Structure

Size Price Stock
5 mg USD 500 Ask For Quote & Lead Time
10 mg USD 850 Ask For Quote & Lead Time
25 mg USD 1800 Ask For Quote & Lead Time
50 mg USD 3000 Ask For Quote & Lead Time
100 mg USD 4650 Ask For Quote & Lead Time

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Description

PROTAC Bcl-xL ligand-1 is a ligand for Bcl-xL that can be used in the synthesis of PROTACs[1].

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

724.63

Formula

C32H29IN4O4S2

SMILES

O=C(C1=C(CCCOC2=CC=C(I)C=C2)SC(N3CCC4=C(C(C(NC5=NC6=CC=CC=C6S5)=O)=CC=C4)C3)=N1)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (69.00 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3800 mL 6.9001 mL 13.8001 mL
5 mM 0.2760 mL 1.3800 mL 2.7600 mL
10 mM 0.1380 mL 0.6900 mL 1.3800 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (2.87 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (2.87 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
PROTAC Bcl-xL ligand-1
Cat. No.:
HY-139304
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