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Cat. No.: HY-160563

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PROTAC ERα Degrader-8

PROTAC ERα Degrader-8 (compound ii-56) is a potent PROTAC degrader of Erα, with DC₅₀ of 0.000006 μM in MCF7 cells.

For research use only. We do not sell to patients.

CAS No.: 3025533-68-7
Formula: C₄₇H₅₁N₅O₄
Molecular Weight:749.94

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PROTAC ERα Degrader-8 Chemical Structure

CAS No.: 3025533-68-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PROTAC ERα Degrader-8 (compound ii-56) is a potent PROTAC degrader of Erα, with DC₅₀ of 0.000006 μM in MCF7 cells^[1].

All PROTACs Isoforms :

All Estrogen Receptor/ERR Isoforms :

Chemical Information

CAS No. 3025533-68-7
Molecular Weight 749.94
Formula C₄₇H₅₁N₅O₄
SMILES

OC1=CC=C2[C@H](C3=CC=C(N([C@@]4([H])C5)[C@](CC4)([H])CC5CN6CCN(C7=CC=C8C(CN([C@@H](CCC9=O)C(N9)=O)C8=O)=C7)CC6)C=C3)[C@H](C%10=CC=CC=C%10)CCC2=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Relay Therapeutics, Inc. Preparation of bifunctional compounds as estrogen receptor alpha degraders and use thereof. World Intellectual Property Organization, WO2024006781 A1 2024-01-04

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
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Chemical Information
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References

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PROTAC ERα Degrader-8

All PROTACs Isoforms

All Estrogen Receptor/ERR Isoforms