ADAMTS Like 5
ADAMTS Like 5 (ADAMTSL5) is a secreted member of the ADAMTS-like subgroup with a marked preference for skin. The protein is produced by keratinocytes, deposited in the epidermal extracellular environment, and reported to associate with fibrillin-1-containing microfibrils, situating it near growth-factor storage sites within the matrix. Elevated ADAMTSL5 expression has been described in psoriatic lesions, and the protein has drawn attention in studies of cutaneous inflammation and wound repair. Recombinant ADAMTSL5 is consequently a focused reagent for skin matrix biology and inflammation-related growth factor research. Transcript profiling places ADAMTSL5 among keratinocyte-derived matrix proteins that change with epidermal differentiation, distinguishing it from the mesenchymal expression typical of other ADAMTS-like members.
