AMPKa1/PRKAA1
PRKAA1 encodes the alpha 1 catalytic subunit of AMP-activated protein kinase, the master cellular energy sensor. Energy stress elevates AMP or ADP, enabling upstream LKB1 or calcium/calmodulin-dependent protein kinase kinase beta to phosphorylate threonine 172. Activated AMPK phosphorylates acetyl-CoA carboxylase and HMG-CoA reductase, shutting down anabolic lipid synthesis, inhibits mechanistic target of rapamycin complex 1 through TSC2 and Raptor phosphorylation, and enhances catabolic ATP production. The alpha 1 isoform predominates in epithelial and hematopoietic compartments, where it links nutrient sensing to cell growth and immune function. Metformin activates AMPK in liver, explaining part of its glucose-lowering action, and AMPK activation protects against ischemic injury.
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AMPKa1/PRKAA1 Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
