AMPKa2/PRKAA2
PRKAA2 encodes the alpha 2 catalytic subunit of AMP-activated protein kinase, the isoform enriched in skeletal muscle, heart, liver, and hypothalamic neurons. Alpha 2-containing heterotrimers localize partly to the nucleus and respond to energetic challenges such as exercise, hypoxia, and ischemia. They stimulate glucose uptake and fatty acid oxidation, promote mitochondrial biogenesis through PGC-1 alpha, and preserve ATP during cardiac stress. Muscle-specific alpha 2 deletion impairs exercise-stimulated glucose uptake, whereas cardiac alpha 2 loss increases susceptibility to ischemic injury and electrical remodeling. Sequence variants in PRKAA2 have been associated with human metabolic traits, and the enzyme remains central to exercise physiology research.
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AMPKa2/PRKAA2 Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
