CD85f/LILRA5
CD85f/LILRA5 is an activating leukocyte immunoglobulin-like receptor with only one extracellular Ig domain and a charged transmembrane residue that couples the receptor to ITAM-containing FcR gamma adaptors. It is expressed broadly on myeloid cells, including monocytes, macrophages, neutrophils, and eosinophils, as well as on NK cells and some T cells, an unusually wide distribution for the LILR family. Ligand engagement promotes inflammatory cytokine production, and LILRA5 signaling cross-talks with Toll-like receptor pathways, shaping inflammatory responses in myeloid cells. The gene lies within the LILR cluster on chromosome 19, adjacent to its inhibitory partners. Recombinant CD85f/LILRA5 is used in adaptor-coupling and myeloid-activation assays.
