CSNK2A2/CK2a2

CSNK2A2 encodes CK2α', the paralogous catalytic subunit of casein kinase 2 and the counterpart of CK2α in this catalog. CK2α' retains the acidophilic consensus preference and the constitutive, second-messenger-independent activity of the holoenzyme, and it assembles with CK2β into α2β2 or mixed αα'β2 tetramers. Its expression is more restricted than that of CK2α, being particularly notable in testis and hematopoietic cells, and gene disruption in mice is compatible with viability, indicating partial redundancy with CK2α. CK2α' contributes to spermatogenesis, immune-cell signaling, and tumor-cell survival. The recombinant protein supports isoform-selective inhibitor testing and studies of paralog-specific substrate recognition.