IFN-alpha 10

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IFN-alpha 10 (IFNA10; IFN-α10), belongs to the alpha/beta interferon (IFN) family, is produced by the macrophages with antiviral activities^[1]. Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively^[2]. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Interferon alpha (IFNa) shows significant biological activity in various cancers, paticularly haematological malignancies such as hairy cell leukaemia and chronic myelogenous leukaemia^[3]. IFNα-10 involves in JAK/STAT signaling pathway with strong signaling effect (EC₅₀=0.3 nM), is identified as potent regulators that reduces both CTLA4 and FOXP3 without affecting cell viability. Therefore, regulatory T cells (Tregs) as the key cells regulating peripheral autoreactive T lymphocytes, IFNα-10 regulates Treg functional states and destabilises Treg^[4].

References:

[1]. Kumagai Y, et al. Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses. Immunity. 2007 Aug;27(2):240-52. [Content Brief]

[2]. Zhang SY, et al. Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-alpha/beta, IFN-gamma, and IFN-lambda in host defense. Immunol Rev. 2008 Dec;226:29-40. [Content Brief]

[3]. Raj NB, et al. Identification of a novel virus-responsive sequence in the promoter of murine interferon-alpha genes. J Biol Chem. 1991 Jun 15;266(17):11360-5. [Content Brief]

[4]. Ding M, et al. Secretome screening reveals immunomodulating functions of IFNα-7, PAP and GDF-7 on regulatory T-cells. Sci Rep. 2021 Aug 18;11(1):16767. [Content Brief]

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IFN-alpha 10 Recombinant Proteins (2)

Species:	Human (2)
Tag:	His (1) Fc (1)
Source:	HEK293 (2)

Cat. No.	Product Name / Synonyms	Species	Source

HY-P76457

IFN-alpha 10/IFNA10 Protein, Human (HEK293, His) Interferon alpha-10; Interferon alpha-6L; Interferon alpha-C; LeIF C	Human	HEK293
IFN-alpha 10 (IFNA10), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 10/IFNA10 Protein, Human (HEK293, His) contains 189 a.a. (M1-D189), produced in HEK293 cells with a C-terminal His-tag.

HY-P76456

IFN-alpha 10/IFNA10 Protein, Human (HEK293, Fc) Interferon alpha-10; Interferon alpha-6L; Interferon alpha-C; LeIF C	Human	HEK293
IFN-alpha 10 (IFNA10), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 10/IFNA10 Protein, Human (HEK293, Fc) contains 166 a.a. (C24-D189), produced in HEK293 cells with a N-terminal hFc-tag.

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IFN-alpha 10

IFN-alpha 10

Subscribe Now to the List of Recombinant Proteins

IFN-alpha 10 Recombinant Proteins (2)