IKKb/IKBKB
Among the catalytic subunits of the IKK complex, IKKβ (IKBKB) is the dominant kinase driving canonical NF-κB activation in response to inflammatory cytokines, Toll-like receptor ligands and stress signals. IKKβ phosphorylates N-terminal serine residues of IκBα and IκBβ, triggering their K48-linked polyubiquitination and proteasomal degradation and releasing NF-κB to induce proinflammatory gene programs. IKKβ also phosphorylates numerous substrates beyond IκB, linking it to insulin signaling, cell survival and tumor promotion. Because sustained IKKβ activity underlies chronic inflammation and inflammation-driven cancer, it is a well-validated drug target. Recombinant IKKβ is widely used for inhibitor screening and NF-κB pathway reconstitution.
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IKKb/IKBKB Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 화학식: Human
- 분자량: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
