PDK4/PDHK4
PDK4 is the fasting- and diabetes-responsive isoform of the pyruvate dehydrogenase kinase family, abundantly expressed in skeletal muscle, heart, liver and adipose tissue. Its gene is induced by glucocorticoids, thyroid hormone and PPAR-alpha/delta ligands during starvation, and the resulting phosphorylation of the PDH E1alpha subunit suppresses glucose oxidation in favor of fatty acid and BCAA catabolism. Persistent PDK4 upregulation is implicated in the hyperglycemia of type 2 diabetes and in muscle wasting, making PDK4 a prominent drug target for metabolic disease. Recombinant PDK4 is used for isozyme-selective inhibitor screening and studies of nutrient-driven metabolic switching.
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PDK4/PDHK4 Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
