PRKD3/PKD3
PKD3, encoded by PRKD3 and also designated PKCν, is the most widely expressed member of the protein kinase D family, with high levels in hematopoietic and immune cells. Activation follows diacylglycerol binding to its C1 domains and phosphorylation by PKCη and other novel PKCs. PKD3 controls cell migration through RhoA and ROCK signaling, regulates mitosis and cytokinesis, and influences Golgi organization and integrin-mediated adhesion. In lymphocytes and monocytes it shapes immune responses, and altered PKD3 activity has been reported in glioma, leukemia and metastatic breast cancer. Its dual role in proliferation and motility makes it an attractive oncology target.
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PRKD3/PKD3 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
