STK35/CLIK1

STK35, initially named CLIK1, is an NKF4-family serine/threonine kinase that localizes to the actin cytoskeleton, the centrosome and mitotic structures in cycling cells. Studies with cell models have linked STK35 to regulation of cell proliferation and to proper progression through the cell cycle, with its depletion impairing proliferation in cultured cells, and it has also been implicated in neuronal development and differentiation contexts. STK35 pairs with the related kinase PDIK1L/CLIK1L in this poorly characterized family, and validated substrates remain scarce. Recombinant STK35 supports investigation of cytoskeletal and centrosomal kinase functions and of cell-cycle control by atypical kinases.