Sclerotigenin: A new antiinsectan benzodiazepine from the sclerotia of penicillium sclerotigenum

  • J Nat Prod. 1999 Apr;62(4):650-2. doi: 10.1021/np980511n.
BK Joshi  1 ,  JB Gloer ,  DT Wicklow ,  PF Dowd
Affiliations
  • 1. Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, and Bioactive Agents Research Unit, Agricultural Research Service, National Center for Agricultural Utilization Research, United States Department of Agriculture, Peoria, Illinois 61.
PMID: 10217735 DOI: 10.1021/np980511n
Abstract

A new benzodiazepine, sclerotigenin (1), was isolated from organic extracts of the sclerotia of Penicillium sclerotigenum (NRRL 3461) along with two known griseofulvin analogues. The structure of 1 was determined primarily by analysis of 1H NMR, 13C NMR, HMQC, and HMBC data. Compound 1 was the major component of the CH2Cl2 extract of P. sclerotigenum sclerotia and is responsible for most of the antiinsectan activity of the extract against the crop pest Helicoverpa zea.

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