Novel oximes having 5-benzyl-2,4-thiazolidinedione as antihyperglycemic agents: synthesis and structure-activity relationship

  • Bioorg Med Chem Lett. 2000 Feb 21;10(4):373-5. doi: 10.1016/s0960-894x(00)00003-2.
H Yanagisawa  1 ,  M Takamura ,  E Yamada ,  S Fujita ,  T Fujiwara ,  M Yachi ,  A Isobe ,  Y Hagisawa
Affiliations
  • 1. Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan. [email protected]
PMID: 10714503 DOI: 10.1016/s0960-894x(00)00003-2
Abstract

Oximes having 5-benzyl-2,4-thiazolidinedione were prepared, and their PPAR gamma agonistic activities and blood glucose lowering activities were evaluated. Biaromatic and methyl groups, attached to the oxime moiety, and the ethylene bridge between oxime and phenoxy groups are favorable to biological activities.