An efficient method for the synthesis of sulbactam pivoxil

  • Farmaco. 2000 Feb;55(2):134-5. doi: 10.1016/s0014-827x(00)00005-7.
L S Changov  1 ,  B K Vassileva ,  M N Confino ,  N N Agapova
Affiliations
  • 1. University of Chemical Technology and Metallurgy, Sofia, Bulgaria. [email protected]
PMID: 10782385 DOI: 10.1016/s0014-827x(00)00005-7
Abstract

Sulbactam pivoxil, a prodrug of the Beta-lactamase Inhibitor sulbactam, was prepared in high yield by reacting the sodium salt of sulbactam with chloromethyl pivalate in a polar solvent, then diluting the reaction mixture with water and isolating the product by filtration. Dimethyl sulfoxide was found to be the solvent of choice among several aprotic organic Solvents.

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