Inhibition of DNA topoisomerases by nidulalin A derivatives

  • Biol Pharm Bull. 2000 Apr;23(4):511-2. doi: 10.1248/bpb.23.511.
S Sato  1 ,  Y Fukuda ,  R Nakagawa ,  T Tsuji ,  K Umemura ,  T Andoh
Affiliations
  • 1. Pharmaceutical Research Laboratories, Ajinomoto Co., Inc., Kawasaki, Japan.
PMID: 10784438 DOI: 10.1248/bpb.23.511
Abstract

Three cytotoxic dihydroxanthone derivatives, nidulalin A(1), F390B(2), and F390C(3) were evaluated for inhibitory activity against DNA topoisomerases. Compounds 1 and 2 inhibited DNA Topoisomerase II with IC50 values of 2.2 microM and 16 microM, and 3 inhibited DNA Topoisomerase I with an IC50 value of 5.9 microM.

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