IB-96212, a novel cytotoxic macrolide produced by a marine Micromonospora. II. Physico-chemical properties and structure determination

  • J Antibiot (Tokyo). 2000 May;53(5):479-83. doi: 10.7164/antibiotics.53.479.
L M Cañedo  1 ,  J L Fernández-Puentes ,  J P Baz
Affiliations
  • 1. Drug Discovery Division, Instituto Biomar SA, León, Spain.
PMID: 10908111 DOI: 10.7164/antibiotics.53.479
Abstract

IB-96212, is a new member of spiroketal containing Macrolide class of fermentation-derived natural products isolated from mycelial extracts of Micromonospora sp. The structure consists of a new aglycone which possesses a 26-membered Macrolide ring system and of one deoxy sugar identified as L-rhodinose, this structure represents the first reported spiroketal Macrolide natural product related to Other macrolides, such as oligomycins, dunaimycins, citovaricin, rutamycin and ossamycin.

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