Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I

  • Bioorg Med Chem Lett. 2000 Oct 2;10(19):2167-70. doi: 10.1016/s0960-894x(00)00441-8.
L D Arnold  1 ,  D J Calderwood ,  R W Dixon ,  D N Johnston ,  J S Kamens ,  R Munschauer ,  P Rafferty ,  S E Ratnofsky
Affiliations
  • 1. BASF Bioresearch Corporation, Worcester, MA 01605-5314, USA.
PMID: 11012021 DOI: 10.1016/s0960-894x(00)00441-8
Abstract

Pyrrolo[2,3-d]pyrimidines containing a 5-(4-phenoxyphenyl) substituent are potent and selective inhibitors of Ick in vitro; some compounds are selective for Lck over Src. Data are shown for two compounds demonstrating that they are potent and selective inhibitors of IL2 production in cells.

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