A novel anti-HIV macrocyclic peptide from Palicourea condensata

  • J Nat Prod. 2001 Feb;64(2):249-50. doi: 10.1021/np000372l.
H R Bokesch  1 ,  L K Pannell ,  P K Cochran ,  R C Sowder 2nd ,  T C McKee ,  M R Boyd
Affiliations
  • 1. Laboratory of Drug Discovery Research and Development, Division of Basic Sciences, NCI-Frederick, Frederick, Maryland 21702-1201, USA.
PMID: 11430013 DOI: 10.1021/np000372l
Abstract

A 37 amino acid cyclic polypeptide has been isolated from the organic extract of the tropical tree Palicourea condensata. Palicourein (1) is the largest of a growing family of plant peptides that contain a cyclized amino acid backbone cross-linked via three internal disulfide bridges. Palicourein inhibits the in vitro cytopathic effects of HIV-1RF Infection of CEM-SS cells with an EC50 value of 0.1 microM and an IC50 value of 1.5 microM.

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