Antitrypanosomal activities of tryptanthrins

  • Antimicrob Agents Chemother. 2002 Mar;46(3):882-3. doi: 10.1128/AAC.46.3.882-883.2002.
John Scovill  1 ,  Elizabeth Blank ,  Michael Konnick ,  Elizabeth Nenortas ,  Theresa Shapiro
Affiliations
  • 1. Department of Chemistry, Bucknell University, Lewisburg, Pennsylvania 17837, USA.
PMID: 11850279 DOI: 10.1128/AAC.46.3.882-883.2002
Abstract

New drugs and molecular targets are needed against Trypanosoma brucei, the protozoan that causes African sleeping sickness. Tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione), a traditional Antifungal agent, and 11 analogs were tested against T. brucei in vitro. The greatest activity was conferred by electron-withdrawing groups in the 8 position of the tryptanthrin ring system; the most potent compound had a 50% effective concentration of 0.40 microM.

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