Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor

  • Bioorg Med Chem Lett. 2002 Mar 11;12(5):779-82. doi: 10.1016/s0960-894x(02)00013-6.
Sabine Barbey  1 ,  Laurence Goossens ,  Thierry Taverne ,  Joséphine Cornet ,  Valérie Choesmel ,  Céline Rouaud ,  Gilles Gimeno ,  Sylvie Yannic-Arnoult ,  Catherine Michaux ,  Caroline Charlier ,  Raymond Houssin ,  Jean Pierre Hénichart
Affiliations
  • 1. Laboratoires Innothera, avenue P. Vaillant-Couturier, BP 10, 94110, Arcueil, France.
PMID: 11859001 DOI: 10.1016/s0960-894x(02)00013-6
Abstract

Dual COX-2/5-LO inhibitors are described as potential new therapeutic agents for inflammatory diseases. A surprisingly potent effect of a 5-LO pharmacophoric group on the COX-2 inhibition is presented as well as pharmacological in vitro and in vivo results.

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