Synthesis and antimycobacterial activity of pyrazine and quinoxaline derivatives

  • J Med Chem. 2002 Dec 5;45(25):5604-6. doi: 10.1021/jm020310n.
Lainne E Seitz  1 ,  William J Suling ,  Robert C Reynolds
Affiliations
  • 1. Organic Chemistry Department, Southern Research Institute, P.O. Box 55305, Birmingham, Alabama 35255-5305, USA.
PMID: 12459027 DOI: 10.1021/jm020310n
Abstract

A series of pyrazine and quinoxaline derivatives have been synthesized, and their activity against M. tuberculosis (Mtb) and Mycobacterium avium (MAC) are reported. The 4-acetoxybenzyl ester of pyrazinoic acid and 4'-acetoxybenzyl 2-quinoxalinecarboxylate showed excellent activity against Mtb (MIC ranges of less than 1-6.25 microg/mL) but only modest activity against MAC (MICs of 4-32 microg/mL).

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