Scabrolides A-D, four new norditerpenoids isolated from the soft coral Sinularia scabra

  • J Nat Prod. 2002 Dec;65(12):1904-8. doi: 10.1021/np020280r.
Jyh-Horng Sheu  1 ,  Atallah F Ahmed ,  Ru-Ting Shiue ,  Chang-Feng Dai ,  Yao-Haur Kuo
Affiliations
  • 1. Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China. [email protected]
PMID: 12502336 DOI: 10.1021/np020280r
Abstract

Four new norditerpenoids, scabrolides A-D (1-4), along with four known ones, 5-8, have been isolated from the dichloromethane extract of the Taiwanese soft coral Sinularia scabra. The structures of 1-4 were elucidated on the basis of extensive spectroscopic analyses, while the relative configurations were determined by the NOESY experiments. The epimeric metabolites 6 and 7 have been shown to exhibit strong cytotoxic activity against KB and Hepa59T/VGH Cancer cell lines.