Callyspongenols A-C, new cytotoxic C22-polyacetylenic alcohols from a red sea sponge, Callyspongia species

  • J Nat Prod. 2003 May;66(5):679-81. doi: 10.1021/np030006c.
Diaa T A Youssef  1 ,  Rob W M van Soest ,  Nobuhiro Fusetani
Affiliations
  • 1. Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
PMID: 12762806 DOI: 10.1021/np030006c
Abstract

Investigation of the organic extract of a Red Sea Sponge, Callyspongia sp., resulted in isolation and identification of three new C(22)-polyacetylenic alcohols, callyspongenols A-C (1-3), together with dehydroisophonochalynol (4). The structures of 1-3 were determined by 1D and 2D NMR studies and mass spectral determinations. Compounds 1-4 showed moderate cytotoxicity against P388 and HeLa cells.