New pyrrolobenzodiazepine antibiotics, RK-1441A and B. II. Isolation and structure

  • Agric Biol Chem. 1990 Nov;54(11):2883-7.
H Osada  1 ,  M Uramoto ,  J Uzawa ,  K Kajikawa ,  K Isono
Affiliations
  • 1. RIKEN (The Institute of Physical and Chemical Research), Saitama, Japan.
PMID: 1368648
Abstract

Antibacteriophage Antibiotics, RK-1441A and B, related to neothramycin were isolated from the culture broth of Streptomyces sp. and their structures were deduced from spectroscopic analyses. The structure of RK-1441A was 8,11-dihydroxy-3,7-dimethoxy-5-oxo-1H-pyrrolo[2,1-c:1,4]benzodiazepine. RK-1441B is a tautomeric mixture at C-3 of the structure, 3,8,11-trihydroxy-7-methoxy-5-oxo-1H-pyrrolo[2,1-c:1,4]benzodiazepine.

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