Anti-aids agents, 6. Salaspermic acid, an anti-HIV principle from Tripterygium wilfordii, and the structure-activity correlation with its related compounds

  • J Nat Prod. 1992 Mar;55(3):340-6. doi: 10.1021/np50081a010.
K Chen  1 ,  Q Shi ,  Y Kashiwada ,  D C Zhang ,  C Q Hu ,  J Q Jin ,  H Nozaki ,  R E Kilkuskie ,  E Tramontano ,  Y C Cheng
Affiliations
  • 1. Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599.
PMID: 1375626 DOI: 10.1021/np50081a010
Abstract

Salaspermic acid [1], an inhibitor of HIV Reverse Transcriptase and HIV replication in H9 lymphocyte cells, was isolated from the roots of Tripterygium wilfordii for the first time. The structure of 1 derived from spectral data was established unequivocally by an X-ray analysis of crystals of the monohydrate. A structure-activity correlation of 1 with ten related compounds indicated that the acetal linkage in ring A and the carboxyl group in ring E of 1 may be required for the anti-HIV activity.

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