New cytotoxic naphthopyrane derivatives from Adenaria floribunda

  • J Nat Prod. 2004 Mar;67(3):451-3. doi: 10.1021/np030223d.
Ahmed A Hussein  1 ,  Icela Barberena ,  Todd L Capson ,  Thomas A Kursar ,  Phyllis D Coley ,  Pablo N Solis ,  Mahabir P Gupta
Affiliations
  • 1. Centro de Investigaciones Farmacognósticas de la Flora Panameña (CIFLORPAN), Facultad de Farmacia, Universidad de Panamá, Apartado 10767, Estafeta Universitaria, Panama, Republic of Panama.
PMID: 15043429 DOI: 10.1021/np030223d
Abstract

Bioassay-guided fractionation of an EtOAc/MeOH extract of Adenaria floribunda young leaves using MCF-7, H-460, and SF-268 Cancer cell lines yielded four new active compounds named adenaflorins A-D (1-4). Their chemical structures were determined by spectroscopic means. Adenaflorin A (1) was the most cytotoxic.