Cytotoxic sterols and saponins from the starfish Certonardoa semiregularis

  • J Nat Prod. 2004 Apr;67(4):584-91. doi: 10.1021/np030427u.
Weihong Wang  1 ,  Jongki Hong ,  Chong-Ok Lee ,  Kwang Sik Im ,  Jae Sue Choi ,  Jee H Jung
Affiliations
  • 1. College of Pharmacy, Pusan National University, Busan 609-735, Korea.
PMID: 15104487 DOI: 10.1021/np030427u
Abstract

Eleven new polyhydroxysterols (1-11) and eight new saponins (12-19) were isolated from the brine shrimp active fraction of the starfish Certonardoa semiregularis. The structures were determined on the basis of spectral analysis and chemical derivatization. The structural variations of these compounds are due to the hydroxylation pattern of the sterol nucleus, the functionalization of the side chain, or the nature and location of the saccharide moiety. These compounds displayed considerable cytotoxicity against a small panel of human solid tumor cell lines.