Hemisynthetic secofriedelane triterpenes with inhibitory activity against the growth of human tumor cell lines in vitro

  • J Nat Prod. 2004 Jul;67(7):1193-6. doi: 10.1021/np0498915.
Cristina Moiteiro  1 ,  César Manta ,  Fátima Justino ,  Regina Tavares ,  Maria João M Curto ,  Madalena Pedro ,  Maria São José Nascimento ,  Madalena Pinto
Affiliations
  • 1. INETI, Instituto Nacional de Engenharia, Tecnologia e Inovação, Estrada do Paço do Lumiar, 1649-038 Lisbon, Portugal. [email protected]
PMID: 15270581 DOI: 10.1021/np0498915
Abstract

Seco acids 7 and 9 and hydroxylated analogues 5 and 6 derived from friedelane Triterpenes were synthesized stereoselectively in high yields. Compounds 5-9 were evaluated for their ability to inhibit in vitro the growth of three human tumor cell lines, MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung Cancer), and SF-268 (CNS Cancer). Only compounds 7 and 9 were found to possess significant growth inhibitory effects, exhibiting GI(50) values that range from 24.6 to 32.8 microM and 10.9 to 17.6 microM, respectively.