A cytotoxic cyclic heptapeptide from the seeds of Annona cherimola

  • J Nat Prod. 2004 Sep;67(9):1577-9. doi: 10.1021/np040068i.
Alassane Wélé  1 ,  Yanjun Zhang ,  Idrissa Ndoye ,  Jean-Paul Brouard ,  Jean-Louis Pousset ,  Bernard Bodo
Affiliations
  • 1. Laboratoire de Chimie Organique et Thérapeutique, Faculté de Médecine et de Pharmacie, Université Cheikh Anta Diop Dakar-Fann, Sénégal. [email protected]
PMID: 15387664 DOI: 10.1021/np040068i
Abstract

From a methanol extract of the seeds of Annona cherimola, a new cyclic heptapeptide, cherimolacyclopeptide C, has been isolated. The structure was elucidated on the basis of the MS/MS fragmentation using a Q-TOF mass spectrometer equipped with an ESI source, extensive 2D NMR experiments, and chemical degradation. Cherimolacyclopeptide C exhibited significant in vitro cytotoxic activity against KB cells, with an IC(50) value of 0.072 microM.