Three new taxane diterpenoids from Taxus sumatrana

  • J Nat Prod. 2005 Jan;68(1):90-3. doi: 10.1021/np040132w.
Ya-Ching Shen  1 ,  Kuen-Ching Cheng ,  Yun-Chi Lin ,  Yuan-Bin Cheng ,  Ashraf Taha Khalil ,  Jih-Hwa Guh ,  Ching-Te Chien ,  Che-Ming Teng ,  Yao-To Chang
Affiliations
  • 1. Institute of Marine Resources, National Sun Yat-sen University, 70 Lien-Hai Road, Kaohsiung, Taiwan 80424, Republic of China. [email protected]
PMID: 15679325 DOI: 10.1021/np040132w
Abstract

Phytochemical investigation of taxane diterpenoidal content of an acetone extract of the leaves and twigs of Taxus sumatrana has resulted in the isolation of three new taxoid compounds, tasumatrols E (1), F (2), and G (3) together with 13 known taxanes (5-16). The structures of these taxanes as well as their derivatives were established on the basis of spectroscopic analyses, especially 1D and 2D NMR. Compounds 1, 2, 12, and 16 exhibited significant cytotoxicity against human A-498, NCI-H226, A549, and PC-3 tumor cells.

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