The immunoepidemiology of human hookworm infection

  • Parasite Immunol. 2004 Nov-Dec;26(11-12):443-54. doi: 10.1111/j.0141-9838.2004.00727.x.
R J Quinnell  1 ,  J Bethony ,  D I Pritchard
Affiliations
PMID: 15771680 DOI: 10.1111/j.0141-9838.2004.00727.x
Abstract

Advances in hookworm immunoepidemiology are reviewed. Recent studies demonstrate a mixed Th1/Th2 response in human hookworm Infection, with immunosuppression of specific and nonspecific IFN-gamma responses. There is increasing evidence for protective immunity in human hookworm Infection, including anti-larval IL-5- and IgE-dependent mechanisms, and for immunological interactions between hookworm Infection and Other Diseases.