Structure-based design of protein tyrosine phosphatase-1B inhibitors

  • Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7. doi: 10.1016/j.bmcl.2005.03.068.
Emma Black  1 ,  Jason Breed ,  Alexander L Breeze ,  Kevin Embrey ,  Robert Garcia ,  Thomas W Gero ,  Linda Godfrey ,  Peter W Kenny ,  Andrew D Morley ,  Claire A Minshull ,  Andrew D Pannifer ,  Jon Read ,  Amanda Rees ,  Daniel J Russell ,  Dorin Toader ,  Julie Tucker
Affiliations
  • 1. AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK.
PMID: 15863305 DOI: 10.1016/j.bmcl.2005.03.068
Abstract

Using structure-based design, a new class of inhibitors of protein tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the 1,2,5-thiadiazolidin-3-one-1,1-dioxide template.

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