Anti-HIV bioactive stilbene dimers of Caragana rosea

  • Planta Med. 2005 Jun;71(6):569-71. doi: 10.1055/s-2005-864162.
Guo-xun Yang  1 ,  Jin-tao Zhou ,  Ya-zun Li ,  Chang-qi Hu
Affiliations
  • 1. School of Pharmacy, Fudan University, Shanghai, P. R. China.
PMID: 15971132 DOI: 10.1055/s-2005-864162
Abstract

Bioassay-guided fractionation of the ethanol extract of the aerial parts of Caragana rosea Turcz. led to the isolation of two new (cararosinol C and cararosinol D) and four known [scirpusin A (1), cis-scirpusin A (2), maackin (3), scirpusin B (4)] stilbene dimers. This is the first identification of these compounds from this plant and the first time that compound 2 has been isolated as a natural compound. Their structures were established mainly by spectral means. An in vitro assay against HIV-1 (IIIB), demonstrated compounds 1 and 4 to be active against HIV, with EC50 values of 10 microg/mL and 7 microg/mL respectively.

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