Hirsutane sesquiterpenes from the fungus Lentinus connatus BCC 8996

  • J Nat Prod. 2005 Nov;68(11):1674-6. doi: 10.1021/np0502286.
Vatcharin Rukachaisirikul  1 ,  Chittreeya Tansakul ,  Saowanit Saithong ,  Chaveng Pakawatchai ,  Masahiko Isaka ,  Rapheephat Suvannakad
Affiliations
  • 1. Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand. [email protected]
PMID: 16309322 DOI: 10.1021/np0502286
Abstract

Two new hirsutane Sesquiterpenes, connatusins A (1) and B (2), were isolated from the fungus Lentinus connatus BCC 8996. The structures, closely related to hypnophilin, were elucidated on the basis of the spectroscopic data. An X-ray analysis was performed to confirm the structure of 1. Six known compounds were also obtained. Panepoxydone (5), panepoxydione (6), and dihydrohypnophilin (8) exhibited significant antimalarial and cytotoxic activities.