Rationally designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis

  • J Med Chem. 2006 Jan 12;49(1):31-4. doi: 10.1021/jm051060o.
Ravindranadh V Somu  1 ,  Helena Boshoff ,  Chunhua Qiao ,  Eric M Bennett ,  Clifton E Barry 3rd ,  Courtney C Aldrich
Affiliations
  • 1. Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, Minnesota 55455, USA.
PMID: 16392788 DOI: 10.1021/jm051060o
Abstract

A rationally designed nucleoside inhibitor of Mycobacterium tuberculosis growth (MIC(99) = 0.19 microM) that disrupts siderophore biosynthesis was identified. The activity is due to inhibition of the adenylate-forming enzyme MbtA which is involved in biosynthesis of the mycobactins.