Cytotoxic ent-abietane diterpenes from Gelonium aequoreum

  • Phytochemistry. 2008 Jan;69(1):276-87. doi: 10.1016/j.phytochem.2007.07.005.
Chia-Lin Lee  1 ,  Fang-Rong Chang ,  Pei-Wen Hsieh ,  Michael-Y Chiang ,  Chin-Chung Wu ,  Zih-You Huang ,  Yu-Hsuan Lan ,  Mei Chen ,  Kuo-Hsiung Lee ,  Hsin-Fu Yen ,  Wen-Chun Hung ,  Yang-Chang Wu
Affiliations
  • 1. Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
PMID: 17714747 DOI: 10.1016/j.phytochem.2007.07.005
Abstract

Seventeen ent-abietane diterpenes, including gelomulides K-X (1-14), and three known compounds, were isolated from a dichloromethane-soluble extract of Gelonium aequoreum through bioassay-guided fractionation. Their structures were identified by spectroscopic methods, and stereochemistry was confirmed by X-ray crystallographic analysis, CD spectral data, and Mosher's method. The isolates were evaluated for in vitro cytotoxic activity, and compounds 1 and 3 showed moderate cytotoxicity against lung (A549), breast (MDA-MB-231 and MCF7), and liver (HepG2) Cancer cell lines.

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