Prenylterphenyllin and its dehydroxyl analogs, new cytotoxic substances from a marine-derived Fungus Aspergillus candidus IF10

  • J Antibiot (Tokyo). 2007 Sep;60(9):586-90. doi: 10.1038/ja.2007.75.
Hong Wei  1 ,  Hirohiko Inada ,  Asami Hayashi ,  Kenichi Higashimoto ,  Patamaporn Pruksakorn ,  Sayo Kamada ,  Masayoshi Arai ,  Shunsuke Ishida ,  Motomasa Kobayashi
Affiliations
  • 1. Graduate School of Pharmaceutical Sciences, Osaka University, Japan.
PMID: 17917243 DOI: 10.1038/ja.2007.75
Abstract

Three novel cytotoxic substances named prenylterphenyllin (1), 4''-deoxyprenylterphenyllin (2), and 4''-deoxyisoterprenin (3) were isolated from a cultured marine-derived fungus of Aspergillus candidus IF10 together with 4''-deoxyterprenin (4). Their chemical structures were elucidated on the basis of 2D NMR analysis. These compounds 1 approximately 4 showed cytotoxic activity against human epidermoid carcinoma KB cells (KB3-1) with IC(50) of 8.5, 3.0, 2.5, and 4.5 microg/ml, respectively.

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