Fusarielin A as an anti-angiogenic and anti-proliferative agent: basic biological characterization

  • Chem Pharm Bull (Tokyo). 2008 Mar;56(3):298-304. doi: 10.1248/cpb.56.298.
Haruka Fujimoto  1 ,  Hiroshi Aoyama ,  Tomomi Noguchi-Yachide ,  Yuichi Hashimoto ,  Hisayoshi Kobayashi
Affiliations
  • 1. Institute of Molecular & Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
PMID: 18310939 DOI: 10.1248/cpb.56.298
Abstract

Fusarielin A shows anti-angiogenic activity in the human umbilical vein endothelial cell (HUVEC) tube formation assay. Structural development studies indicated the importance of the hydroxyl groups in this molecule. A 3H-labeled derivative and a fluorescent affinity-labeling agent were prepared and used to examine the cellular distribution and biological behavior of fusarielin A.

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