A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis

  • Mol Cell. 2008 Feb 29;29(4):409-10. doi: 10.1016/j.molcel.2008.02.005.
Atsushi Tanaka  1 ,  Richard J Youle
Affiliations
  • 1. Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20824, USA.
PMID: 18313377 DOI: 10.1016/j.molcel.2008.02.005
Abstract

DRP1, a member of the Dynamin family of large GTPases, mediates mitochondrial fission. In a recent issue of Developmental Cell, Cassidy-Stone et al. (2008) identified mdivi-1, a new DRP1 inhibitor that prevents mitochondria division and Bax-mediated mitochondrial outer membrane permeabilization during Apoptosis.

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