Alpha-glucosidase inhibitor from Bergenia ligulata

  • J Oleo Sci. 2008;57(8):431-5. doi: 10.5650/jos.57.431.
Junichi Saijyo  1 ,  Yousuke Suzuki ,  Yoshiharu Okuno ,  Hidehiko Yamaki ,  Takuya Suzuki ,  Mitsuo Miyazawa
Affiliations
  • 1. Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Higashiosaka-shi, Osaka, Japan.
PMID: 18622126 DOI: 10.5650/jos.57.431
Abstract

Inhibitory compound of alpha-glucosidase activity, (+)-afzelechin (1), was isolated from rhizomes of Bergenia ligulata. The structure was identified by IR, EI-MS, (1)H and (13)C NMR spectroscopy. The ID(50) (50% inhibition dose) value of compound 1 was 0.13 mM. To investigate the structure-activity relationship, (+)-afzelechin tetraacetate (2), (+)-5,7,4'-trimethoxyafzelechin (3), (+)-tetramethoxyafzelechin (4), and (+)-3-acetyl-5,7,4'-trimethoxyafzelechin (5) as the derivatives of compound 1 were evaluated as well.

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