Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7

  • Bioorg Med Chem Lett. 2008 Sep 15;18(18):4932-5. doi: 10.1016/j.bmcl.2008.08.058.
Weihong Zheng  1 ,  Alexei Degterev ,  Emily Hsu ,  Junying Yuan ,  Chengye Yuan
Affiliations
  • 1. State Key Laboratory of Bio-organic and Natural Product Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
PMID: 18768316 DOI: 10.1016/j.bmcl.2008.08.058
Abstract

Necroptosis is a regulated caspase-independent cell death mechanism characterized by morphological features resembling non-regulated necrosis. Necrotatin-7 (Nec-7), a novel potent small-molecule inhibitor of Necroptosis, is structurally distinct from previously described necrostatins (Nec-1, Nec-3, Nec-4 and Nec-5). Here, we describe a series of structural modifications and the structure-activity relationship (SAR) of the Nec-7 series for inhibiting Necroptosis.

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