Cytotoxic guanidine alkaloids from Pterogyne nitens

  • J Nat Prod. 2009 Mar 27;72(3):473-6. doi: 10.1021/np800612x.
Luis Octávio Regasini  1 ,  Ian Castro-Gamboa ,  Dulce Helena Siqueira Silva ,  Maysa Furlan ,  Eliezer Jesus Barreiro ,  Paulo Michel Pinheiro Ferreira ,  Cláudia Pessoa ,  Letícia Veras Costa Lotufo ,  Manoel Odorico de Moraes ,  Maria Claudia Marx Young ,  Vanderlan da Silva Bolzani
Affiliations
  • 1. Institute of Chemistry, Nucley of Bioassay, Biosynthesis and Ecophysiology of Natural Products, NuBBE, Sao Paulo State University, UNESP, Araraquara, SP, Brazil.
PMID: 19159272 DOI: 10.1021/np800612x
Abstract

As part of a bioprospecting program aimed at the discovery of potential Anticancer drugs, two new guanidine-type Alkaloids, nitensidines D and E (1, 2), and the known pterogynine (3), pterogynidine (4), and galegine (5), were isolated from the leaves of Pterogyne nitens. The structures of 1 and 2 were established on the basis of spectroscopic data interpretation. These compounds were tested against a small panel of human Cancer cell lines. Compound 2 exhibited cytotoxicity for HL-60 (human myeloblastic leukemia) and SF-245 (human Glioblastoma) cells.