Stimulatory action of calcium L-threonate on ascorbic acid uptake by a human T-lymphoma cell line

  • Life Sci. 1991;49(19):1377-81. doi: 10.1016/0024-3205(91)90388-r.
M J Fay  1 ,  A J Verlangieri
Affiliations
  • 1. Department of Pharmacology, University of Mississippi School of Pharmacy, University 38677.
PMID: 1943443 DOI: 10.1016/0024-3205(91)90388-r
Abstract

The effects of preincubation of human T-lymphoma cells with increasing concentrations of calcium L-threonate on the uptake of L-[1-14C]ascorbic acid were examined. Calcium L-threonate (0-1,000 mg%) stimulated ascorbic acid (1.25 mg%) uptake in a dose-dependent manner. These results indicate that calcium threonate and possibly Other ascorbic acid metabolites have biological activity and potential pharmacological applications.

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