Cytotoxic diterpenoids from Croton argyrophylloides

  • J Nat Prod. 2009 Oct;72(10):1884-7. doi: 10.1021/np900250k.
Hélcio S Santos  1 ,  Francisco W A Barros ,  Maria Rose Jane R Albuquerque ,  Paulo N Bandeira ,  Claúdia Pessoa ,  Raimundo Braz-Filho ,  Francisco J Q Monte ,  Jose Henrique Leal-Cardoso ,  Telma L G Lemos
Affiliations
  • 1. Centro de Ciências Exatas e Tecnologia, Universidade Estadual Vale do Acaraú, 62040-370, Sobral, CE, Brazil.
PMID: 19780590 DOI: 10.1021/np900250k
Abstract

Two new diterpenes, 1 and 2, together with the known ent-15-oxo-kaur-16-en-18-oic acid (3), were isolated from the bark of Croton argyrophylloides. The structural characterization of 1 and 2 was determined on the basis of spectroscopic data interpretation. The cytotoxicity of each compound was evaluated against HL-60 (leukemia), MDAMB-435 (melanoma), SF-295 (glioblastoma), and HCT-8 (colon carcinoma) human tumor cell lines and against human peripheral blood mononuclear cells. The hemolytic potential in mouse erythrocytes was also tested for 1-3.