2-dodecanol (decyl methyl carbinol) inhibits hyphal formation and SIR2 expression in C. albicans

  • J Basic Microbiol. 2009 Dec;49(6):579-83. doi: 10.1002/jobm.200900035.
Crystale Siew-Ying Lim  1 ,  Won-Fen Wong ,  Rozita Rosli ,  Kee-Peng Ng ,  Heng-Fong Seow ,  Pei-Pei Chong
Affiliations
  • 1. Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, University Putra Malaysia, Serdang, Selangor, Malaysia.
PMID: 19810039 DOI: 10.1002/jobm.200900035
Abstract

Candida albicans is capable of undergoing yeast-hypha transition to attain pathogenicity in humans. In this study, we investigated the differential expression of CaSIR2 via quantitative Real-Time PCR (qPCR), during yeast-hypha transition with and without the presence of 2-dodecanol. SIR2 transcript levels were found to be significantly enhanced after hyphal induction as compared to the yeast form. This study found that 2-dodecanol is able to inhibit hyphal development and block SIR2 up-regulation, even in hyphal-inducing growth conditions. We suggest that SIR2 may be involved in Candida albicans quorum-sensing and serum-induced yeast-hyphae transition via the Ras1-cAMP-Efg1 signalling cascade.

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