c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration

  • FEBS Lett. 2010 Jan 4;584(1):15-21. doi: 10.1016/j.febslet.2009.11.009.
Anna Baruzzi  1 ,  Ilaria Iacobucci ,  Simona Soverini ,  Clifford A Lowell ,  Giovanni Martinelli ,  Giorgio Berton
Affiliations
  • 1. Department of Pathology, University of Verona, Verona, Italy.
PMID: 19903482 DOI: 10.1016/j.febslet.2009.11.009
Abstract

Cytoskeleton dynamics are regulated by Src-family tyrosine Kinases (SFKs) and c-Abl. We found that the SFK members HCK and c-Fgr regulate tyrosine phosphorylation of c-Abl and c-Abl associates with beta1 integrin-bound HCK or c-Fgr in murine Macrophages. Studies with selective inhibitors and cells from SFK-deficient mice showed that c-Abl and SFK regulate migration and activation of the small GTPases Cdc42 and Rac in Macrophages. Additionally, human neutrophil chemotactic activity was reduced by c-Abl inhibitors, and neutrophils from chronic myeloid leukaemia patients displayed an increased chemotactic ability. Hence, Src-family kinase and c-Abl cross-talk in the regulation of myeloid cell migration.