Aporphine and bisaporphine alkaloids from Aristolochia lagesiana var. intermedia

  • Phytochemistry. 2010 Mar;71(4):469-78. doi: 10.1016/j.phytochem.2009.11.010.
Marcia L R Ferreira  1 ,  Inara C de Pascoli ,  Isabele R Nascimento ,  Julio Zukerman-Schpector ,  Lucia M X Lopes
Affiliations
  • 1. Instituto de Química, São Paulo State University, UNESP, C.P. 355, 14801-970 Araraquara, SP, Brazil.
PMID: 20036405 DOI: 10.1016/j.phytochem.2009.11.010
Abstract

Corydines, isocorydines, and analogous Aporphine Alkaloids were isolated from the leaves of Aristolochia lagesiana var. intermedia, together with three bisaporphine salts (lagesianines B-D). Their structures were determined by chemical derivatizations and spectroscopic analyses. Lagesianines B and C are the first examples of N-CH(2)-N' and C-2-O-C-1' linked dimeric Aporphine Alkaloids, respectively, while the monomeric units of lagesianine D, which has a carbon skeleton, are linked through C-7-C-5'via an ethane-1,2-diol group (C-7-CHOHCHOH-C-5').

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