Anti-influenza diarylheptanoids from the bark of Alnus japonica

  • Bioorg Med Chem Lett. 2010 Feb 1;20(3):1000-3. doi: 10.1016/j.bmcl.2009.12.057.
Nguyen Huu Tung  1 ,  Hyuk-Joon Kwon ,  Jae-Hong Kim ,  Jeong Chan Ra ,  Yan Ding ,  Jeong Ah Kim ,  Young Ho Kim
Affiliations
  • 1. College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea.
PMID: 20045319 DOI: 10.1016/j.bmcl.2009.12.057
Abstract

This study to investigate anti-influenza components from the bark of Alnus japonica resulted in the isolation of two rare acylated diarylheptanoids, named oregonoyl A (5) and oregonoyl B (6), along with nine known compounds (1-4 and 7-11). Their structures were elucidated on the basis of extensive spectroscopic and chemical methods. Antiviral testing of compounds 1-11 against KBNP-0028 (H9N2) avian Influenza Virus showed that platyphyllone (10) was strongly active, and platyphyllonol-5-xylopyranoside (9) was moderately active against KBNP-0028 as compared with the positive control, zanamivir, respectively.

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